論文

関藤 孝之 河田(河野) 美幸 秋山 浩一

関藤 孝之

原著論文

  • Kawano-Kawada M, Chardwiriyapreecha S, Manabe K, Sekito T, Akiyama K, Takegawa K, Kakinuma Y. The amino-terminal hydrophilic region of the vacuolar transporter Avt3p is dispensable for the vacuolar amino acid compartmentalization of Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2016 in press
  • Manabe K, Kawano-Kawada M, Ikeda K, Sekito T, Kakinuma Y. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2016 80(6):1125-1130.
  • Kawano-Kawada M, Pongcharoen P, Kawahara R, Yasuda M, Yamasaki T, Akiyama K, Sekito T,Kakinuma Y. Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2016 ;80(2):279-287.

  • Soracom Chardwiriyapreecha, Kunio Manabe, Tomoko Iwaki, Miyuki Kawano-Kawada, Takayuki Sekito, Siriporn Lunprom, Koichi Akiyama, Kaoru Takegawa, Yoshimi Kakinuma Functional expression and characterization of Schizosaccharomyces pombe Avt3p as a vacuolar amino acid exporter in Saccharomyces cerevisiae.PLoS ONE, 10: e0130542 (2015)
  • Junichi Tone, Ayumi Yoshimura, Kunio Manabe, Nami Murao, Takayuki Sekito, Miyuki Kawano-Kawada, Yoshimi Kakinuma Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem., 79, 782–789 (2015)
  • Junichi Tone, Atsushi Yamanaka, Kunio Manabe, Nami Murao, Miyuki Kawano-Kawada, Takayuki Sekito, Yoshimi Kakinuma A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem., 79, 190-195 (2015)
  • Chardwiriyapreecha S, Manabe K, Iwaki T, Kawano-Kawada M, Sekito T, Lunprom S, Akiyama K, Takegawa K, Kakinuma Y.Functional Expression and Characterization of Schizosaccharomyces pombe Avt3p as a Vacuolar Amino Acid Exporter in Saccharomyces cerevisiae. PLoS One. 2015;10(6):e0130542. 
  • Lunprom S, Pongcharoen P, Sekito T, Kawano-Kawada M, Kakinuma Y, Akiyama K.Characterization of vacuolar amino acid transporter from Fusarium oxysporum in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2015 ;79(12):1972-1979.
  • Tone J, Yamanaka A, Manabe K, Murao N, Kawano-Kawada M, Sekito T, Kakinuma Y : A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 79(2):190-195. (2015)
  • Tone J, Yoshimura A, Manabe K, Murao N, Sekito T, Kawano-Kawada M, Kakinuma Y : Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 79(5): 782–789 (2015)
  • Sekito T, Sugimoto N, Ishimoto M, Kawano-Kawada M, Akiyama K, Nishimoto S, Sugahara T, Kakinuma Y : Tributyltin induces cell cycle arrest at G1 phase in the yeast Saccharomyces cerevisiae. J. Toxicol. Sci. 39(2):311-317. (2014)
  • Sekito T, Chardwiriyapreecha S, Sugimoto N, Ishimoto M, Kawano-Kawada M, Kakinuma Y : Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 78(6):969-975. (2014)
  • Sekito T, Nakamura K, Manabe K, Tone J, Sato Y, Murao N, Kawano-Kawada M, Kakinuma Y : Loss of ATP-dependent lysine uptake in the vacuolar membrane vesicles of Saccharomyces cerevisiae ypq1∆ mutant. Biosci. Biotechnol. Biochem. 78(7):1199-1202. (2014)
  • Pongcharoen P, Kawano-Kawada M, Iwaki T, Sugimoto N, Sekito T, Akiyama K, Takegawa K, Kakinuma Y.: Functional Expression of Schizosaccharomyces pombe Vba2p in Vacuolar Membrane of Saccharomyces cerevisiae. Biosci Biotechnol Biochem.77(9):1988-1990. (2013)
  • Shimazu, M., Itaya, T., Pongcharoen, P., Sekito, T., Kawano-Kawada, M., and Kakinuma, Y. : Vba5p, a novel plasma membrane protein involved in amino acid uptake and drug sensitivity in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem., 76(10):1993-1995.(2012)
  • Ishimoto, M., Sugimoto, N., Sekito, T., Kawano-Kawada, M., and Kakinuma, Y. : ATP-dependent export of neutral amino acids by vacuolar membrane vesicles of Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem., 76(9):1802-1804.(2012)
  • Sugimoto, N., Iwaki, T., Chardwiriyapreecha, S., Shimazu, M., Kawano, M., Sekito, T., Takegawa, K., and Kakinuma, Y. (2011) Atg22p, a vacuolar membrane protein involved in the amino acid compartmentalization of Schizosaccharomyces pombe.
    Biosci. Biotechnol. Biochem. 75:385-387.
  • Akiyama, K., Iwaki, T., Sugimoto, N., Chardwiriyapreecha, S., Kawano, M., Nishimoto, S., Sugahara, T., Sekito, T., and Kakinuma, Y. (2011) Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
    J. Toxicol. Sci. 36:117-120.
  • Sugimoto, N., Iwaki, T., Chardwiriyapreecha, S., Shimazu, M., Sekito, T., Takegawa, K., and Kakinuma, Y. (2010) Vba2p, a vacuolar membrane protein involved in basic amino acid transport in Schizosaccharomyces pombe.Biosci.
    Biotechnol. Biochem. 74:2166-2169.
  • Iwaki, T., Sekito, T., and Kakinuma, Y. (2010) Vacuolar amino acid transporter Avt5p is responsible for lithium uptake in Schizosaccharomyces pombe.
    Biosci. Biotechnol. Biochem. 74:1719-1721.
  • Chardwiriyapreecha, S., Mukaiyama, H., Sekito, T., Iwaki, T., Takegawa, K., and Kakinuma, Y. (2010) Avt5p is required for vacuolar uptake of amino acids in the fission yeast Schizosaccharomyces pombe.
    FEBS Lett. 584:2339-2345.
  • Sekito T, Kawamata T, Ichikawa R, Suzuki K, Ohsumi Y. (2009) Atg17 recruits Atg9 to organize the pre-autophagosomal structure.
    Genes Cells 14:525-38.
  • Obara, K., Sekito, T., Niimi, K., and Ohsumi, Y. (2008) The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential function.
    J. Biol. Chem. 283:23972-23980.
  • Kawamata, T., Kamada, Y., Kabeya, Y., Sekito, T. and Ohsumi, Y (2008) Organization of the pre-autophagosomal structure responsible for autophagosome formation.
    Mol. Biol. Cell 19:2039-2050.
  • Suzuki, K., Kubota, Y., Sekito, T.* and Ohsumi, Y (2007) Hierarchy of Atg proteins in pre-autophagosomal structure organization.
    Genes Cells, 12, 209-218.
  • Obara K., Sekito T. and Ohsumi Y. (2006) Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the preautophagosomal structure in Saccharomyces cerevisiae.
    Mol. Biol. Cell, 17:1527-1539.
  • Liu Z., Sekito T., Spirek M, Thornton J. and Butow R. A. (2003) Rtrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p.
    Mol. Cell, 12:401-411.
  • Sekito T., Liu Z., Thornton J. and Butow R. A. (2002) RTG-dependent mitochondria-to-nucleus signaling is regulated by MKS1 and is linked to formation of yeast prion [URE3].
    Mol. Biol. Cell, 13:795-804.
  • Liu Z., Sekito T., Epstetin C.B. and Butow R.A. (2001) RTG-dependent mitochondoria to nucleus signaling is negatively regulated by the seven WD-repeat protein Lst8p.
    EMBO J., 20:7209-7219.
  • Sekito T. , Thornton T. and Butow R.A. (2000) Mitochondria-to-nuclear signaling is regulated by the subcellular localization of the transcription factors Rtg1p and Rtg3p.
    Mol. Biol. Cell, 11:2103-2115.

総説

  • 関藤 孝之、柿沼 喜己(2016) 液胞/リソソーム膜を介したアミノ酸輸送の分子機構. 化学と生物, 54, 324-334

  • Sekito T., Fujiki Y., Ohsumi Y. and Kakinuma Y. (2008) Novel families of vacuolar amino acid transporters.IUBMB Life, 60, 519-525.

  • Kamada Y., Sekito T. and Ohsumi Y. (2004) Autophagy in yeast: a TOR-mediated response to nutrient starvation.
    Curr. Top. Microbiol. Immunol., 279:73-84.
  • 中戸川 仁、花田 孝雄、鎌田 芳彰、小原 圭介、関藤 孝之(2006)オートファゴソームを紡ぎ出す5つのAtgタンパク質群. 
    蛋白質核酸酵素 8月増刊号:1457-1463.
  • 関藤 孝之、大隅 良典(2003) 酵母の飢餓応答-オートファジー研究の進展. 
    清酒酵母の研究~90年代の研究~ 46-49.                          ページトップへ

河田(河野) 美幸

原著論文

  • Kawano-Kawada M, Chardwiriyapreecha S, Manabe K, Sekito T, Akiyama K, Takegawa K, Kakinuma Y. The amino-terminal hydrophilic region of the vacuolar transporter Avt3p is dispensable for the vacuolar amino acid compartmentalization of Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2016 in press
  • Manabe K, Kawano-Kawada M, Ikeda K, Sekito T, Kakinuma Y. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2016 80(6):1125-1130
  • Kawano-Kawada M, Pongcharoen P, Kawahara R, Yasuda M, Yamasaki T, Akiyama K, Sekito T,Kakinuma Y. Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2016 ;80(2):279-287.
  • Soracom Chardwiriyapreecha, Kunio Manabe, Tomoko Iwaki, Miyuki Kawano-Kawada,Takayuki Sekito, Siriporn Lunprom, Koichi Akiyama, Kaoru Takegawa, Yoshimi Kakinuma Functional expression and characterization of Schizosaccharomyces pombe Avt3p as a vacuolar amino acid exporter in Saccharomyces cerevisiae.PLoS ONE, 10: e0130542 (2015)

  • Lunprom S, Pongcharoen P, Sekito T, Kawano-Kawada M, Kakinuma Y, Akiyama K. Characterization of vacuolar amino acid transporter from Fusarium oxysporum in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2015 ;79(12):1972-1979.

  • Tone J, Yamanaka A, Manabe K, Murao N, Kawano-Kawada M, Sekito T, Kakinuma Y : A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 79(2):190-195. (2015)
  • Tone J, Yoshimura A, Manabe K, Murao N, Sekito T, Kawano-Kawada M, Kakinuma Y : Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem. 79(5): 782–789 (2015)
  • Sekito T, Sugimoto N, Ishimoto M, Kawano-Kawada M, Akiyama K, Nishimoto S, Sugahara T, Kakinuma Y : Tributyltin induces cell cycle arrest at G1 phase in the yeast Saccharomyces cerevisiae. J. Toxicol. Sci. 39(2):311-317. (2014)
  • Kumagai K, Kawano-Kawada M, Hanada K : Phosphoregulation of the Ceramide Transport Protein CERT at Serine 315 in the Interaction with VAMP-associated Protein (VAP) for Inter-organelle Trafficking of Ceramide in Mammalian Cells. J. Biol. Chem. 289(15):10748-10760. (2014)
  • Sekito T, Chardwiriyapreecha S, Sugimoto N, Ishimoto M, Kawano-Kawada M, Kakinuma Y : Vacuolar transporter Avt4 is involved in excretion of basic amino acids from the vacuoles of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 78(6):969-975. (2014)
  • Sekito T, Nakamura K, Manabe K, Tone J, Sato Y, Murao N, Kawano-Kawada M, Kakinuma Y : Loss of ATP-dependent lysine uptake in the vacuolar membrane vesicles of Saccharomyces cerevisiae ypq1∆ mutant. Biosci. Biotechnol. Biochem. 78(7):1199-1202. (2014)
  • Pongcharoen P, Kawano-Kawada M, Iwaki T, Sugimoto N, Sekito T, Akiyama K, Takegawa K, Kakinuma Y.: Functional Expression of Schizosaccharomyces pombe Vba2p in Vacuolar Membrane of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 77(9):1988-1990. (2013)
  • Kawano-Kawada, M., Iwaki, T., Hosaka, T., Murata, T., Yamato, I., Homma, M., and Kakinuma, Y. : Mutagenesis of the residues forming an ion binding pocket of the NtpK subunit of Enterococcus hirae V-ATPase. J. Bacteriol., 194(17):4546-4549.(2012)
  • Shimazu, M., Itaya, T., Pongcharoen, P., Sekito, T., Kawano-Kawada, M., and Kakinuma, Y.: Vba5p, a novel plasma membrane protein involved in amino acid uptake and drug sensitivity in Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem., 76(10):1993-1995.(2012)
  • Ishimoto, M., Sugimoto, N., Sekito, T., Kawano-Kawada, M., and Kakinuma, Y. : ATP-dependent export of neutral amino acids by vacuolar membrane vesicles of Saccharomyces cerevisiae. Biosci. Biotechnol. Biochem., 76(9):1802-1804.(2012)
  • Watanabe, S., Morimoto, D., Fukumori, F., Shinomiya, H., Nishiwaki, H., Kawano-Kawada, M., Sasai, Y., Tozawa, Y., and Watanabe, Y.: Identification and characterization of D-hydroxyproline dehydrogenase and Δ1-pyrroline-4-hydroxy-2-carboxylate deaminase involved in novel L-hydroxyproline metabolism of bacteria: metabolic convergent evolution.
    J. Biol. Chem., 287(39):32674-32688.(2012)
  • Kawano-Kawada M, Takahashi H, Igarashi K, Murata T, Yamato I, Homma M, Kakinuma Y. (2011) The significance of a glutamate-139 residue of V-type Na+-ATPase NtpK subunit in its catalytic turnover linked with salt tolerance of Enterococcus hirae.
    J Bacteriol.193: 3657-3661.
  • Sugimoto N, Iwaki T, Chardwiriyapreecha S, Shimazu M, Kawano M, Sekito T, Takegawa K, Kakinuma Y. (2011)Atg22p, a vacuolar membrane protein involved in the amino acid compartmentalization of Schizosaccharomyces pombe.
    Biosci Biotechnol Biochem. 75:385-387.
  • Akiyama K, Iwaki T, Sugimoto N, Chardwiriyapreecha S, Kawano M, Nishimoto S, Sugahara T, Sekito T, Kakinuma Y. (2011) Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
    J Toxicol Sci. 36:117-120.
  • Manabe T, Kawano M, Kawasaki K. (2010)Mutations in the lipid A deacylase PagL which release the enzyme from its latency affect the ability of PagL to interact with lipopolysaccharide in Salmonella enterica serovar Typhimurium.
    Biochem Biophys Res Commun. 396:812-816.
  • Kawano, M., Manabe, T., and Kawasaki, K. (2010) Salmonella enterica serovar Typhimurium lipopolysaccharide deacylation enhances its intracellular growth within macrophages.
    FEBS Lett. 584: 207 212
  • Saito S., Matsui H., Kawano M., Kumagai K., Tomishige N., Hanada K., Echigo S., Tamura S., and Kobayashi T.(2008) Protein Phosphatase 2Cepsilon is an endoplasmic reticulum integral membrane protein that dephosphorylates the ceramide transport protein CERT to enhance its association with organelle membranes.
    J. Biol. Chem. 283: 6584-6593
  • Kumagai K., Kawano M., Shinkai-Ouchi F., Nishijima M., and Hanada K. (2007) Inter-organelle trafficking of ceramide is regulated by phosphorylation-dependent co-operativity between the PH and START domains of CERT.
    J. Biol. Chem. 282:17758-17766
  • Kawano M., Kumagai K., Nishijima M., and Hanada K. (2006) Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAP-interacting FFAT motif of CERT.
    J. Biol. Chem. 281:30279-30288
  • Hanada, K., Kumagai, K., Yasuda, S., Miura, Y., Kawano, M., Fukasawa, M., and Nishijima, M. (2003) Molecular machinery for non-vesicular trafficking of ceramide.
    Nature 426:803-809
  • ページトップへ

    秋山 浩一

    原著論文

    • Kawano-Kawada M, Chardwiriyapreecha S, Manabe K, Sekito T, Akiyama K, Takegawa K, Kakinuma Y. The amino-terminal hydrophilic region of the vacuolar transporter Avt3p is dispensable for the vacuolar amino acid compartmentalization of Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2016 in press
    • Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T, Yamauchi S. Effect of the structure of dietary epoxylignan on its cytotoxic activity: relationship between the structure and the activity of 7,7'-epoxylignan and the introduction of apoptosis by caspase 3/7. Biosci Biotechnol Biochem. 2016; 80(4):669-675.
    • Yamauchi S, Isozaki Y, Nishiwaki H, Akiyama K. Syntheses of natural 1,3-polyol/α-pyrone and its all stereoisomers to estimate antifungal activities against plant pathogenic fungi. Bioorg Med Chem Lett. 2015;25(10):2189-2192.
    • Kawano-Kawada M, Pongcharoen P, Kawahara R, Yasuda M, Yamasaki T, Akiyama K, Sekito T,Kakinuma Y. Vba4p, a vacuolar membrane protein, is involved in the drug resistance and vacuolar morphology of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2016 ;80(2):279-287
    • Soracom Chardwiriyapreecha, Kunio Manabe, Tomoko Iwaki, Miyuki Kawano-Kawada,             Takayuki Sekito, Siriporn Lunprom, Koichi Akiyama, Kaoru Takegawa, Yoshimi Kakinuma Functional expression and characterization of Schizosaccharomyces pombe Avt3p as a vacuolar amino acid exporter in Saccharomyces cerevisiae.PLoS ONE, 10: e0130542 (2015)
    • Lunprom S, Pongcharoen P, Sekito T, Kawano-Kawada M, Kakinuma Y, Akiyama K. Characterization of vacuolar amino acid transporter from Fusarium oxysporum in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 2015 ;79(12):1972-1979.
    • Sekito T, Sugimoto N, Ishimoto M, Kawano-Kawada M, Akiyama K, Nishimoto S, Sugahara T, Kakinuma Y : Tributyltin induces cell cycle arrest at G1 phase in the yeast Saccharomyces cerevisiae. J. Toxicol. Sci. 39(2):311-317. (2014)
    • Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T, Yamauchi S. Cytotoxic activity of butane type of 1,7-seco-2,7'-cyclolignanes and apoptosis induction by Caspase 9 and 3. Bioorg Med Chem Lett. 2014;24(17):4231-4235.

    • Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T, Yamauchi S. Cytotoxic activity of dietary lignan and its derivatives: structure-cytotoxic activity relationship of dihydroguaiaretic acid. J Agric Food Chem. 2014;62(23):5305-5315.
    • Hasebe A, Nishiwaki H, Akiyama K, Sugahara T, Kishida T, Yamauchi S. Quantitative structure-activity relationship analysis of antifungal (+)-dihydroguaiaretic acid using 7-phenyl derivatives. J Agric Food Chem. 2013;61(36):8548-8555.
    • Yamauchi S, Kawahara S, Wukirsari T, Nishiwaki H, Nishi K, Sugahara T, Akiyama K, Kishida T. Structure-cytotoxic activity relationship of sesquilignan, morinol A. Bioorg Med Chem Lett. 2013;23(17):4923-4930.
    • Pongcharoen P, Kawano-Kawada M, Iwaki T, Sugimoto N, Sekito T, Akiyama K, Takegawa K, Kakinuma Y.: Functional Expression of Schizosaccharomyces pombe Vba2p in Vacuolar Membrane of Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 77(9):1988-1990. (2013)
    • Nishiwaki, H., Ouchi, M., Matsugi, J., Akiyama, K.,Sugahara, T., Kishida, T., and Yamauchi, S. : Effect of substituents at phenyl group of 7,7'-dioxo-9,9'-epoxylignane on antifungal activity. Bioorg. Med. Chem. Lett., 22(21):6740-6744.(2012)
    • Tominaga S, Nishi K, Nishimoto S, Akiyama K, Yamauchi S, Sugahara T. (-)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice.(2012)
      Food Funct. 3(1), 76-82,
    • Akiyama K, Tone J, Yamauchi S, Sugahara T, Maruyama M, Kakinuma Y. (2011) Disruption of ion homeostasis by verrucosin and a related compound.
      Biosci Biotechnol Biochem, 75(5):1000-1002.
    • Yamawaki M, Nishi K, Nishimoto S, Yamauchi S, Akiyama K, Kishida T, Maruyama M, Nishiwaki H, Sugahara T.Immunomodulatory effect of (-)-matairesinol in vivo and ex vivo.
      Biosci Biotechnol Biochem. 2011,75(5),859-863, 2011.
    • Nishimoto S, Akiyama K, Kakinuma Y, Kitamura S, Sugahara T. (2011) Heavy oil fraction induces the dysplastic sperm in male mouse.
      J Toxicol Sci. 36(4):487-491.
    • Akiyama, K., Tone, J., Okabe, M., Nishimoto, S., Sugahara, T., and Kakinuma, Y. (2011) Inhibition of myotube formation by paraquat in the myoblast cell line C2C12.
      J. Toxicol. Sci. 36:243-246.
    • Akiyama, K., Iwaki, T., Sugimoto, N., Chardwiriyapreecha, S., Kawano, M., Nishimoto, S., Sugahara, T., Sekito, T., Kakinuma, Y. (2011) Bfr1p is responsible for tributyltin resistance in Schizosaccharomyces pombe.
      J. Toxicol. Sci. 36:117-120.
    • Masuda, K., Nishiwaki, H., Akiyama, K., Yamauchi, S., Maruyama, M., Sugahara, T., and Kishida, T. (2010) Antifungal activity of morinol B derivatives of tetrahydropyran sesquilignan.
      Biosci. Biotechnol. Biochem. 74:2071-2076.
    • Kawahara, S., Iwata, I., Fujita, E., Yamawaki, M., Nishiwaki, H., Sugahara, T., Yamauchi, S., Akiyama, K., and Kishida, T. (2010) IgE-suppressive activity of (-)-matairesinol and its structure-activity relationship.
      Biosci. Biotechnol. Biochem. 74:1878-1883.
    • Ogura, K., Sugahara, T., Maruyama, M., Akiyama, K., and Yamauchi, S. (2010) Improved syntheses of morinol C and D by employing Mizoroki-Heck reaction and their cytotoxic and antimicrobial activities.
      Biosci. Biotechnol. Biochem. 74:1641-1644.
    • Okabe, M., Nishimoto, S., Sugahara, T., Akiyama, K., and Kakinuma, Y. (2010) Oral administration of paraquat perturbs immunoglobulin productivity in mouse.
      J. Toxicol. Sci., 35: 257-263.
    • Omokawa, Y., Miyazaki, T., Walde, P., Akiyama, K., Sugahara, T., Masuda, S., Inada, A., Ohnishi, Y., Saeki, T., and Kato, K. (2010) In vitro and in vivo anti-tumor effects of novel Span 80 vesicles containing immobilized Eucheuma serra agglutinin.
      Int. J. Pharm. 389:157-167.
    • Kawaguchi, Y., Yamauchi, S., Masuda, K., Nishiwaki, H., Akiyama, K., Maruyama, M., Sugahara, T., Kishida, T., and Koba, Y. (2009) Antimicrobial activity of stereoisomers of butane-type lignans.
      Biosci. Biotechnol. Biochem. 73:1806-1810.
    • Nakato, T., Yamauchi, S., Tago, R., Akiyama, K., Maruyama, M., Sugahara, T., Kishida, T., Koba, Y. (2009) Syntheses and antimicrobial activity of tetrasubstituted tetrahydrofuran lignan stereoisomers.
      Biosci. Biotechnol. Biochem. 73:1608-1617.
    • Tominaga, S., Sugahara, T., Nishimoto, S., Yamawaki, M., Nakashima, Y., Kishida, T., Akiyama, K., Maruyama, M., and Yamauchi, S. (2009) The Effect of Secoisolariciresinol on 3T3-L1 Adipocytes and the Relationship between Molecular Structure and Activity.
      Biosci. Biotechnol. Biochem. 73:35-9.
    • Akiyama, K., Yamauchi, S., Maruyama, M., Sugahara, T., Kishida, T., and Koba Y. (2009) Antimicrobial activity of stereoisomers of morinols A and B, tetrahydropyran sesquineolignans.
      Biosci. Biotechnol. Biochem. 73:129-33.
    • Yamauchi, S., Masuda, T., Sugahara, T., Kawaguchi, Y., Ohuchi, M., Someya, T., Akiyama, J., Tominaga, S., Yamawaki, M., Kishida, T., Akiyama, K., and Maruyama, M. (2008) Antioxidant activity of butane type lignans, secoisolariciresinol, dihydroguaiaretic Acid, and 7,7'-oxodihydroguaiaretic Acid.
      Biosci. Biotechnol. Biochem. 72:2981-2986.
    • Nishimoto, S., Goto, Y., Morishige, H., Shiraishi, R., Doi, M., Akiyama, K., Yamauchi, S., and Sugahara, T. (2008) Mode of action of the immunostimulatory effect of collagen from jellyfish.
      Biosci. Biotechnol. Biochem. 72:2806-2814.
    • Yoshida, T., Yamauchi, S., Tago, R., Maruyama, M., Akiyama, K., Sugahara, T., Kishida, T., and Koba, Y. (2008) Syntheses of all stereoisomers of goniodiol from yeast-reduction products and their antimicrobiological activity.
      Biosci. Biotechnol. Biochem. 72:2342-2352.
    • Tago R, Yamauchi S, Maruyama M, Akiyama K, Sugahara T, Kishida T, Koba Y. (2008) Structure-antibacterial activity relationship for 9-O,9'-O-demethyl (+)-virgatusin.
      Biosci. Biotechnol. Biochem. 72:1032-1037.
    • Nakato, T., Tago, R., Akiyama, K., Maruyama, M., Sugahara, T., Kishida, T., and Yamauchi, S. (2008) Stereoselective construction of tetra-substituted tetrahydrofuran compounds from benzylic hemiacetal in the presence of H2 and a Pd catalyst: stereoselective synthesis of a stereoisomer of (-)-virgatusin and its antimicrobiological activity.
      Biosci. Biotechnol. Biochem. 72:197-203.
    • Sugahara, T., Yamauchi, S., Kondo, A., Ohno, F., Tominaga, S., Nakashima, Y., Kishida, T., Akiyama, K., and Maruyama, M (2007) First stereoselective synthesis of meso-secoisolariciresinol and comparison of its biological activity with (+) and (-)-secoisolariciresinol.
      Biosci. Biotechnol. Biochem., 71(12) : 2962-2968.
    • Yamauchi, S., Nakato, T., Tsuchiya, M., Koichi, Akiyama, K., Maruyama, M., Sugahara, T., and Kishida, T (2007) Use of the benzyl mesylate for the synthesis of tetrahydrofuran lignan: syntheses of 7,8-trans, 7′,8′-trans, 7,7′-cis, and 8,8′-cis-virgatusin stereoisomers.
      Biosci. Biotechnol. Biochem., 71(9) : 2248-2255.
    • Akiyama K., Maruyama, M., Yamauchi, S., Nakashima, Y., Nakato, T., Tago, R., Sugahara, T., Kishida, T., and Koba, Y (2007) Antimicrobiral actibity of lignan: effect of benzylic oxygene and stereochemistry of 2,3-dibenxyl-4-butanolid and 3,4-dibenzyltetrahydrofuran lignans on activity.
      Biosci. Biotechnol. Biochem., 71(7) : 1745-1751.
    • Kouichi Akiyama, Hatsue Katakami, Renkichi Takata (2007) Mobilization of a retrotransposon in 5-azacytidine-treated fungus Fusarium oxysporum,
      Plant Biotechnology , 24(3):345-348.
    • Yamauchi S, Sugahara T, Akiyama K, Maruyama M, Kishida T.(2007) Determination of the Stereochemistry of the Tetrahydropyran Sesquineolignans lMorinols A and B.
      J Nat Prod., 70:549-556.
    • Koichi Akiyama, Satoshi Yamauchi, Tomofumi Nakato, Masafumi Maruyama, Takuya Sugahara, Taro Kishida (2007) Antifungal Activity of Tetra-Substituted Tetrahydrofuran Lignan, (-)-Virgatusin, and Its Structure-Activity Relationship,
      Biosciences Biotechnology and Biochemistry,71(4):1028-1035.
    • Satoshi Yamauchi, Takuya Sugahara, Koichi Akiyama, Masafumi Maruyama, Taro Kishida (2007) Antibacterial Activity of Virgatusin-Related Compound,
      Biosciences Biotechnology and Biochemistry, 71(3):677-680.
    • Kato, K., Walde, P., Koine, N., Imai, Y., Akiyama, K. and Sugahara, T (2006) Molecular composition of non-ionic vesicles prepared from Span 80 or Span 85 by a two-step emulsification method.
      Journal of Dispersion Science Technology, 27: 1217-1222.
    • Yamauchi, S., Sugahara, T., Nakashima, Y., Okada, A., Akiyama, K.*, Kishida, T., Maruyama, M. and Masuda, T (2006) Radical and superoxide scavenging activity of matairesinol and oxidized Matairesinol.
      Biosciences Biotechnology and Biochemistry, 70 (8): 1934-1940.
    • S. Yamauchi, T. Sugahara, Y. Nakashima, K. Abe, Y. Hayashi, K. Akiyama, T. Kishida, M. Maruyama (2006) Effect of Benzylic Oxygen on the Cytotoxic Activity for Colon 26 Cell Line of Phenolic Lignans,
      Biosciences Biotechnology and Biochemistry, 70(12):2942-2947.
    • Shimizu, M., Ikegami, T., Akiyama, K. and Morita, H (2006) A Novel Way to Express Proline-Selectively Labeled Proteins with a Wheat Germ Cell-Free Protein Synthesis System.
      J. Biochem., 140: 453-456.
    • Yuki Fukuda, Takuya Sugahara, Masashi Ueno, Yusuke Fukuta, Yukari Ochi, Koichi Akiyama, Tatsuhiko Miyazaki, Seizo Masuda, Akihiro Kawakubo, Keiichi Kato(2006) The anti-tumor effect of Euchema serra agglutinin (ESA) on colon cancer cells in vitro and in vivo.
      Anti-cancer Drugs, 17(8), 943-947.
    • Takuya Sugahara, Masashi Ueno, Yoko Goto, Ryusuke Shiraishi, Mikiharu Doi, Koichi Akiyama, Satoshi Yamauchi (2006) SImmunostimulation Effect of the Jellyfish Collagen
      Biosciences Biotechnology and Biochemistry, 70(9):2131-2137.
    • Masamitsu Shimazu, Takayuki Sekito, Koichi Akiyama, Yoshinori Ohsumi, and Yoshimi Kakinuma (2005) A Family of Basic Amino Acid Transporters of the Vacuolar Membrane from Saccharomyces cerevisiae ,
      J. Biol. Chem. 280: 4851-4857.
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